Inactivation of Cone-Specific Phototransduction Genes in Rod Monochromatic Cetaceans
نویسندگان
چکیده
1 Department of Biology, University of California, Riverside, Riverside, CA, USA, 2 Museum of Vertebrate Zoology, University of California, Berkeley, Berkeley, CA, USA, 3 Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, USA, 4 Department of Biology, San Diego State University, San Diego, CA, USA, 5 Southwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, La Jolla, CA, USA, 6 Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, USA
منابع مشابه
Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses.
G-Protein receptor kinase 1 (GRK1) ("rhodopsin kinase") is necessary for the inactivation of photoactivated rhodopsin, the light receptor of the G-protein transduction cascade of rod photoreceptors. GRK1 has also been reported to be present in retinal cones in which its function is unknown. To examine the role of GRK1 in retinal cone signaling pathways, we measured in mice having null mutations...
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Rod monochromacy is a rare condition in vertebrates characterized by the absence of cone photoreceptor cells. The resulting phenotype is colourblindness and low acuity vision in dim-light and blindness in bright-light conditions. Early reports of xenarthrans (armadillos, sloths and anteaters) suggest that they are rod monochromats, but this has not been tested with genomic data. We searched the...
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Arrestins are proteins that arrest the activity of G protein-coupled receptors (GPCRs). While it is well established that normal inactivation of photoexcited rhodopsin, the GPCR of rod phototransduction, requires arrestin (Arr1), it has been controversial whether the same requirement holds for cone opsin inactivation. Mouse cone photoreceptors express two distinct visual arrestins: Arr1 and Arr...
متن کاملCone and rod ERG phototransduction parameters in retinitis pigmentosa.
PURPOSE To analyze cone and rod phototransduction parameters from ERG a-waves in patients with RP and to determine the relationships among these parameters, age, and mode of inheritance. METHODS Sets of four white flashes (3.2-4.4 log scotopic troland [scot td-s]) were presented in the dark. The same stimuli were later presented against a rod-saturating background and the generated cone a-wav...
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تاریخ انتشار 2016